Sentence examples for achieve an efficacious from inspiring English sources

Involved parties need to understand the fundamental perspectives across disciplines to collaboratively achieve an efficacious design.

Gabapentin requires titration to achieve an efficacious dose so that the rate and severity of adverse effects are minimised.

Like many of the medications used for chronic pain, gabapentin requires titration to achieve an efficacious dose so that the rate and severity of adverse effects are minimised.

While these are important examples of advances in vaccine design and construction, optimization of the glycoconjugate multivalent constructs as well as their formulation is still required to achieve an efficacious anticancer vaccine.

Based on the pharmacokinetic results in this study, a daily dose of 160 mg for 3 days is able to achieve an efficacious exposure AUC0 24 of at least 1,800 ng · h/ml, which is equivalent to the efficacious dose in mice, while a daily dose of 400 mg for 3 days or a single dose of 800 mg is able to maintain a total plasma concentration greater than the MIC for 6 days.

This novel approach uses a limited input inoculum relative to the tumour cell mass, and thus achieves an efficacious outcome that has so far eluded other vaccine, immunotherapeutic or gene therapeutic strategies where there is a requisite for the majority of tumour cells to be transduced for beneficial outcome to be achieved.

Macitentan is a novel dual ETA/ETB receptor antagonist with enhanced tissue distribution and sustained receptor binding properties designed to achieve a more efficacious ET receptor blockade.

51, 52, 68, 69 The overall results from the dose selection analyses suggested that the lowest lasofoxifene dose necessary to achieve a fully efficacious response on BMD and low-density lipoprotein cholesterol (LDL-C) levels is 0.25 mg/day.

The overall results from the dose selection analyses suggested that the lowest lasofoxifene dose necessary to achieve a fully efficacious response on BMD and LDL-C levels is 0.25 mg/day.

Testing of specific genes is being used increasingly to predict response to drugs: the results of such tests can indicate whether a drug should not be used because of the risk of adverse events, or whether the dose to achieve a safe and efficacious outcome should be modified (15).

Therefore, it may be possible to achieve a balance of efficacious relief of endometrial-related symptomatic pain, e.g., as measured by endometriosis symptom severity score (ESSS), and minimally associated BMD loss, without "add back" therapy, if an optimal range for estrogen suppression can be identified and targeted.