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At any time point, a patient in a clinical trial must achieve a tender joint count (TJC) ≤1, a swollen joint count (SJC) ≤1, C-reactive protein (CRP) ≤1 mg/dl, a patient global assessment (PGA) ≤1, or, as an index- based score, an SDAI ≤3.3, to be considered in remission.
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In studies of ≥6 months' duration, placebo patients who did not achieve a decrease in tender and swollen joints of at least 20% were advanced to tofacitinib at Month 3.
I found the awesome rib chop, looking like a blunt weapon on the plate, awfully fatty, but the swaggering porterhouse came through in a big way, seared aggressively to achieve a deep crunch, all rubescent tender meat within.
Be careful as a strong boil will make the chicken tough and dry; try to achieve a slow simmer so that the chicken gets tender and moist.
Placebo patients who failed to achieve a 10% improvement from baseline in both swollen and tender joints at weeks 14 and 16 underwent mandatory escape to active treatment in a blinded manner.
Placebo patients who failed to achieve a 10% improvement from baseline in both swollen and tender joints at weeks 14 and 16 were eligible for blinded mandatory escape to active treatment.
Others achieve a simple dignity.
Control of symptoms was rapid: more than 50% achieved a 20% reduction in the number of tender and swollen joints within a fortnight (ACR20 response), and 90% achieved this within 6 weeks.
Mr. Rana's seek kebabs, little cylinders of ground goat, cilantro and tomato baked in the tandoori oven, remain moist and tender after broiling, and marinated lamb, smeared with a ginger-mint paste, achieves a luscious velvety texture.
Nirvana achieved a lot of things with Unplugged, not least proving that underneath the musical melee was a band of tender, soulful and sensitive types.
In recent trials, DAS28 remission rates exceeded ACR70 response rates [ 23- 26], meaning that more patients achieved a state of DAS28 remission than the proportion of patients reaching a decrease of 70% or higher in tender and swollen joints.
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