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A total of 56% (5/9) breast and 50% (11/22) of ovarian tumours achieved >95% inhibition at clinically achievable concentrations.
Despite these apparently encouraging results, MMC alone achieves >95% inhibition at clinically achievable concentrations in just 14% of oesophagogastric tumours (three out of 21) and 10% of colorectal tumours (four out of 39) tested.
Achievable concentrations for various dosages are described in Table 1.
For the purpose of redox imaging, 3-CP was shown to be an optimal choice based on the achievable concentrations and bioreduction observed in vivo.
Using a ratio design, this study established that combining pharmacologically achievable concentrations of ascorbate with gemcitabine resulted in a synergistic cytotoxic response in eight pancreatic tumor cell lines.
With extended exposure (6 days) both T- and B-precursor ALL cells appeared sensitive at clinically achievable concentrations (Figure 2B).
At clinically achievable concentrations, HDACIs that simultaneously inhibited both HDACs 1 and 6 showed the best anti-leukemic activities and significantly enhanced cytarabine-induced apoptosis.
Leukaemic patient cells and the CCRF-CEM cell line was treated with therapeutically achievable concentrations (10, 30 and 50 nM) of digitoxin in 96-well microtiter plates.
The in vitro study showed that antituberculous drugs did not exert any inhibitory effect on IFN-γ production within the range of therapeutically achievable concentrations.
At clinically achievable concentrations, only the drugs (LBH-589 and PXD101) which simultaneously inhibited both HDACs 1 and 6 showed the best antileukemic activities and significantly enhanced cytarabine-induced apoptosis.
Based on the above information, we decided to examine the biological effects of FAs in a concentration range of 10−10 M–10−5 M, which are physiologically achievable concentrations.
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