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The preponderance of electromigration is thus demonstrated as well as the existence of a maximum achievable concentration, the predicted value of which is confirmed experimentally.
Thus the highest achievable concentration of free l-rhamnose in the used RG-medium (10 g l−1) should be 1.3 g l−1.
In this chapter, the potential advantages of athermal membrane processes for the concentration of liquid foods and natural colors have been successfully demonstrated with respect to maximum achievable concentration, improved product quality, ease of scale up, and low energy consumption.
Assessment of achievable concentration of Cenersen in different biologic matrices will be useful to elucidate the biological and clinical activity of this promising drug and define its recommended dose in future clinical trials.
It was also found that, if there would be no band broadening in the trap, the achievable concentration enhancement would be the same for either a strong or weakly retaining trap.
Seven of the 10 EGFR mutant lines were sensitive at a clinically achievable concentration (<1 µM).
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A total of 56% (5/9) breast and 50% (11/22) of ovarian tumours achieved >95% inhibition at clinically achievable concentrations.
Despite these apparently encouraging results, MMC alone achieves >95% inhibition at clinically achievable concentrations in just 14% of oesophagogastric tumours (three out of 21) and 10% of colorectal tumours (four out of 39) tested.
Therefore, the concentration of LBH589 required to achieve 50% growth inhibition in our colon cancer cells was well within clinically achievable concentrations whereas the concentration of vorinostat was within, but approaching the upper limit of reported serum concentration ranges.
Achievable concentrations for various dosages are described in Table 1.
For the purpose of redox imaging, 3-CP was shown to be an optimal choice based on the achievable concentrations and bioreduction observed in vivo.
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