The phrase "ache up" is not correct and does not appear to be a standard expression in written English.
It is unclear what context or meaning you intend to convey with this phrase, as it does not have a recognized usage.
Example: "After the long hike, I could feel the ache up my legs."
Alternatives: "pain in" or "soreness in".
Specifically, AChE up-regulation in anxiety (32, 33) could suppress ACh levels, intercepting ACh blockade of inflammation (30), whereas the miR-608 target CDC42 interacts with collybistin in GABAergic neurons and is actively involved in the formation of the anxiolytic GABAA receptor synapse (25, 34).
As mentioned above, the reduced AChE activity found in cortical-enriched extracts could stimulate AChE up-regulation in these brain areas.
In addition, AChE up-regulation has been demonstrated in reaction to chronic inhibition; rats administered with the organophosphate insecticide chlorpyrifos show a dose-dependent decrease in the activity of brain AChE, while immunoreactive AChE protein increased after 3 weeks of treatmen with the higher doses (Chiappa et al., 1995).
Like all of us, it aches, sending up moans from the pit we balance on the edge of.
He trembles with emotion while absorbing the news of his fate, the outcome of his struggles with the legal system and it's hard not to ache and tear up as realization sinks in for him.
Maddy CostaThere are introverted teenage girls who will long to be Lykke Li, and men of all ages who will ache to sweep her up in their arms and protect her.
For example, in parts of California a sugar craving can be squelched by zooming into a Baskin-Robbins; the ensuing stomach ache cured by driving up to a service window at a Walgreens pharmacy.
It will not go well for your wallet, and your stomach will ache when you total up the bill.
You almost ache for a dial-up modem.
So she gets up aching not only from her position but from lack of sleep altogether.
