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We propose that conformational dynamics of APC/CCDC20-MCC modulate E2 activation and determine distinctive ubiquitination activities as part of a response mechanism ensuring accurate sister chromatid segregation.
The precise regulation of the spindle apparatus, a bipolar array of highly dynamic microtubules (MTs), is indispensable for accurate sister chromatid segregation and genome stability.
This Janus-like mode of action provides an efficient way of controlling chromosome segregation after checking that everything is ready, which is a crucial requirement for accurate sister chromatid separation.
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Kinetochores mediate microtubule chromosome attachment and ensure accurate segregation of sister chromatids.
Spindle assembly checkpoint (SAC) is a surveillance mechanism safeguards the accurate separation of sister chromatids (Musacchio, 2015).
However, cohesion in centromeric regions must be preserved during meiosis I to ensure the accurate segregation of sister chromatids during meiosis II.
However, cohesin around the centromeres is protected from cleavage during meiosis I, which is essential for the accurate segregation of sister chromatids during meiosis II.
All eukaryotic cells are thought to utilize a mitotic spindle to ensure accurate inheritance of sister chromatids to the daughter cells, but it has long been a mystery how such a complicated structure might have evolved.
He always pronounced it in strangled Franglais because, to be fair to him, it could never sound quite the same in English; 'a fine herb omlette' would have made him sound like some hedgerow-erian which is, instead, a more accurate description of my sister.
Thus, while HR allows for accurate repair by a sister chromatid in mitotic cells, it is limited to the S and G2 phases of the cell cycle.
HR provides accurate recombination using a sister chromatid as a template which maintains genomic stability.
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