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Eligible patients must have: ≥1 lesion that can be accurately measured at baseline, and is suitable for accurate repeated measurements; ECOG performance status 0 1; life expectancy >12 weeks.
Furthermore, liver metastases are more suitable for accurate repeated measurements in contrast to the primary tumour which may be mobile and therefore difficult to capture in the same position from scan to scan.
Primary tumours were evaluated by both FLT/PET and RECIST, but because of difficulties in performing accurate repeated measures due to mobility of the primary tumour, these measures were not included in the RECIST and FLT/PET comparison.
Target lesions were selected on the basis of their size (lesions with the longest diameter) and their suitability for accurate repeated measurements.
Target lesions were selected based on size (longest diameter) and suitability for accurate repeated measurements (RECIST) [ 15].
Similar(55)
The strengths of this study are its large sample size and use of accurate, repeat assessments of all examined variables, use of the FRS based on clinical measurements, and ascertainment of diabetes based on the standard 75-g OGTT at each clinical study cycle (23, 24).
Consequently, we aimed to develop accurate repeat detection methods and comprehensive cataloging of repetitive sequences.
Target lesions were selected on the basis of their size and their suitability for accurate repeat measurements according to the reviewer criteria.
Using zebrafish and medaka as example organisms, we show that accurate repeat masking is an important factor for obtaining a high quality clustering.
Recent advances in next generation sequencing and accurate repeat genotyping algorithms enabled us to investigate repeat variation in tumor genomes more comprehensively, and to study their potential consequences on gene expression.
Acquiring accurate and repeated measurements of these parameters for hygroscopic densified biomass are not straightforward and only a few methods are available.
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