Sentence examples for accurate imputation from inspiring English sources

For crop species lacking a high-quality reference genome, like hexaploid wheat, genetically ordered markers allow the implementation of marker-order−dependent but highly accurate imputation algorithms (e.g., FSFHap) to impute genotypic data with a large proportion of missing data points so that QTL/gene mapping can be done precisely.

This approach, by taking disease status into account when imputing, could theoretically lead to more accurate imputation and powerful association test.

This phenomenon is likely to be caused by the fact that SNPMStat uses only a small number of SNPs to impute, which may lead to a less accurate imputation in low or medium LD level and, consequently, to a higher genotyping error that could inflate type-I error of association test [26].

Accurate imputation of SNP with rare alleles (MAF ≤0.05) is important especially when the imputed genotypes are to be used in association studies.

We have shown that the polymorphisms identified in the 80 accessions can be used for highly accurate imputation of polymorphisms in strains that have only been analyzed with the 216k SNP array.

Moreover, because the finite sample bias of 2SLS is not monotonically decreasing in the degree of measurement accuracy, the most accurate imputation method is not necessarily the method that minimizes the bias of 2SLS.

Poland et al. [ 14] showed that a random forest imputation method provided the most accurate imputations, but the effect on genomic prediction accuracy was not significant.

The chained equations method has produced accurate imputations in various settings [ 9], but the overall theory that proves its correctness is currently being developed.

Their method was able to achieve accurate imputations (r > 0.4) in instances when the two E-MAPs shared over 64% of their genes.

Note also that when imputing at markers that are completely untyped in X (in silico genotyping), basing imputations on p (X ^ mis | H ) rather than p (X ^ mis | X obs, H ) may actually yield more accurate imputations (Guan and Stephens 2008).

AlphaImpute is a flexible and accurate genotype imputation tool that was originally designed for the imputation of genotypes on autosomal chromosomes.