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Bipolar centrosomes assembly during metaphase is crucial for bipolar spindle formation and accurate chromosomes segregation in cells undergoing mitosis [ 6, 7].
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DOI: http://dx.doi.org/10.7554/eLife.03676.002 In eukaryotes, accurate chromosome segregation relies on specific chromosomal regions called centromeres that recruit components of the proteinaceous kinetochore complex to mediate spindle attachments and ensure high-fidelity segregation (DeWulf and Earnshaw, 2008).
Pericentromeres consist of repetitive tandem satellite repeats and are crucial chromosomal elements that are responsible for accurate chromosome segregation in mitosis.
Aurora kinase-B migrates as part of the chromosomal passenger complex, whose function is to ensure accurate chromosome segregation and cell body division (Ducat and Zheng, 2004; Fu et al, 2007; Lens and Voest, 2010).
The chromosomal passenger complex (CPC) plays a pivotal role in controlling accurate chromosome segregation and cytokinesis during cell division.
Meiotic crossover (CO) recombination facilitates evolution and accurate chromosome segregation.
To ensure accurate chromosome segregation, it performs three major functions using disparate molecular mechanisms.
Crossing-over ensures accurate chromosome segregation during meiosis, and every pair of chromosomes obtains at least one crossover, even though the majority of recombination sites yield non-crossovers.
The multiprotein kinetochore complex must assemble at a specific site on each chromosome to achieve accurate chromosome segregation.
Kinetochores form a dynamic interface with the microtubules from the mitotic spindle to achieve accurate chromosome segregation.
Mitosis also sees a substantial wave of protein phosphorylation, controlling signaling events that coordinate mitotic processes and ensure accurate chromosome segregation.
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