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Recently Kiewiet et al [17] update the diagnostic accuracy summary estimates for imaging modalities described by Shea et al [9], by using state-of-the-art methods for the meta-analysis of diagnostic accuracy studies: in this systematic review, they observed that cholescintigraphy has the highest diagnostic accuracy of all imaging modalities in the detection of acute cholecystitis.
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With this approach we can assess the significance of clusters and estimate the accuracy of summary statistics, based on the proportion of bootstrap networks that support the observation (see Fig. 1).
This is addressed by detailed additions to the paper including: 1) A quantitative analysis of the accuracy with summary statistics.
Log2−transformation of all FPKM values allows datasets to be more normally distributed, lending greater accuracy to summary statistics while drastically reducing the number of outliers.
Statistical binning (weighted and unweighted) are new techniques aimed at improving the estimation of gene trees in a multi-locus phylogenomic analysis, when individual genes have low signal, and have both been shown to improve the accuracy of summary methods [ 27].
In order to guarantee the accuracy of summaries, a circulation system of these synthesis documents between collaborating professionals will be implemented, to allow verification of the validity or to effect clarifications and changes in the content, results and conclusions obtained.
Others highlighted challenges, such as concerns about the accuracy of summaries and the disruption of trying to "keep up" (interviewee 5), and difficult to catch "new long words…" (interview 17).
We compare summaries by calculating Accuracy for each summary as in Equation (1).
These reviews could present summary accuracy measures generated in a meta-analysis or present a range of accuracy measures without a summary measure.
If a meta-analysis was conducted, information was also extracted for the summary accuracy measures.
This analysis was carried out according to standard methods for pooling studies of diagnostic accuracy using the summary ROC approach[ 14].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com