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Reviewer #2: The manuscript "The β-hairpin of 40S exit channel protein Rps5/uS7 promotes efficient and accurate translation initiation in vivo" represents an important contribution to the problem of accuracy mechanisms in protein synthesis.
Your manuscript represents an important contribution to the problem of accuracy mechanisms in protein synthesis, and the role of the small ribosomal subunit protein Rps5 in translation initiation site selection.
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Venanzi and Parenti-Castelli [16] proposed a method to evaluate the influence of clearances on accuracy of mechanisms, which works for both planar and spatial mechanisms.
The fundamental tenet of our hypotheses (H-1 and H-2) – to be tested – is that a deficient energy supply to rapidly firing neurons (the lactate shuttle) underlies moment-to-moment fluctuations in response speed and accuracy (astrocyte mechanisms) and, in the long-term, episodes of lactate deficiency during development delays axon myelination (oligodendrocyte function).
Accuracy and mechanism of these methods are very different.
Even though the ligand-binding assay can be performed readily with desirable precision and accuracy, the mechanism of action could involve downstream events post ligand-binding.
In addition, a significant portion of the existing professionally produced three-dimensional cell and molecular visualizations used in the classroom lack the requisite scientific accuracy and mechanism-based design approaches that we believe are critical in the context of education.
It was found that the correct pattern of flame expansion and overall flame appearance were predicted with reasonable accuracy with both mechanisms, but the detailed mechanism resulted in expansion rates closer to the experiment.
The calibration system employed an automatic-error-retrieval and accuracy-control mechanism based on a set of ground-truth data.
The path accuracy of parallel mechanisms depends on both the mechanical design and the motion control algorithm that minimizes the following error.
The proposed failure mode model predicts with accuracy the failure mechanisms.
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CEO of Professional Science Editing for Scientists @ prosciediting.com