This observation would support the hypothesis that mitochondrial dysfunction does not directly cause α-synuclein accumulation; indeed, to date, there is not strong enough functional evidence that mitochondrial dysfunction impacts directly on α-synuclein homeostasis [ 175 ▪, 176 ▪], though there is some evidence supporting the opposite [ 98, 175 ▪, 177 ▪, 178, 179▪▪, 180 ▪, 181 ▪].
While additional research will advance scientific understanding of the relationship between air pollution and health, public health officials should consider taking action based on the accumulation of research to date.
To date accumulation of the Aβ in the retina has mostly been studied in the transgenic AD murine models to investigate whether toxic Aβ in the retina may cause visual disturbances in patients with AD.
To date, accumulations of corrosion products on these same materials on shipwrecks in freshwater environments have not had an icicle shape (2014 email communication from Ley S; unreferenced).
To date, PHB accumulation has been reported for a few cyanobacterial species with photoautotrophic PHB production reaching less than 10% of dry cell weight (dcw) (Bhati et al. 2010).
To date, the accumulation of evidence literature is mostly composed of electrophysiological experiments with primates.
Although bone-specific Tregs have not been proven to exist to date, the accumulation of Tregs at sites of intense bone remodeling (i.e., the epiphysis of long bones) favors the concept that Treg cells need cell-to-cell contact and act locally on bone.
Sixty-four diffexpressedy expressedatete proteins (Table 2) showed opposite transient accumulation to previously reported expression changes in fruits such as tomato, strawberry and apple.
In addition to presence or absence of pigmentation, anthocyanin biosynthetic genes can also modify the profile of pigments and tissue-specific accumulation [ 3, 25] and to date, few studies in carrot have explored these factors affecting the relative accumulation of different anthocyanin pigments in purple-colored tissues.
This experiment provides the best evidence to date that the accumulation of random mitochondrial DNA mutations induces aging-related dysfunction, he says.
A key factor that has limited the success of this approach to date is insufficient accumulation of the engineered protein variants in vivo due to their improper folding and/or reduced stability, compared to the native protein.
