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If the treatment of compound obviously causes the accumulation of virus at the host membrane region, this compound is believed to inhibit the entry of virus.
Here, we introduced a transendothelial route of delivery in order to increase tumor accumulation of virus particles (vp) beyond that resulting from convection-dependent extravasation alone.
At present, we do not have an explanation for the rapid accumulation of virus at early time points after infection in DBA/2J mice.
Accumulation of virus capsid protein and non-capsid proteins 3C, 3A, and 3AB was delayed in MG132 treated cells (Fig. 4 C, D).
Taken in the context of a requirement for gE in axonal transport of HSV1 and for accumulation of virus at the periphery of epithelial cells [20], [44], [45], [55], [56], [57], [58], and of our results in fixed epithelial cells infected with gEnull virus reported here, these live cell observations suggest a potential role for gE in viral transport within epithelial cells.
It was shown that platelet depletion diminished accumulation of virus specific Tc-lymphocytes and minimized organ damage.
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Accumulation of virus-derived small RNAs from TCV, but not those from Cucumber Mosaic Virus (CMV) or Turnip Mosaic Virus (TuMV), was impaired in the Arabidopsis dcl2 mutant concomitant with its hyper-susceptibility to TCV, suggesting a role of DCL2 in viral small RNA biogenesis [10].
In our model, such trade-off is a straightforward consequence of growth rate modifications: in harsh conditions for the host, accumulation of viruses in cells favours virions production, i.e. virus horizontal transmission, at the expense of host survival, i.e. virus vertical transmission.
The platelets Causes hepatic injury by promoting accumulation of virus-specific CD8 T cells.
This may lead to the accumulation of virus-related products in non-infected cells (Pegtel et al., 2010).
Additionally, platelets were also implied to be involved in accumulation of virus-nonspecific CD8+ T cells and other virus-nonspecific inflammatory cells including NK cells during acute hepatitis in a mouse model [ 19, 20, 47].
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