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By contemplating that we are the doer of this and that, we accumulate an ego which is mere accumulation of thoughts and create an ore of misery for ourselves.
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Put another way, your current state is the uncompromising and unyielding accumulation of all of your past thoughts - good and bad.
The infectious agent of these diseases is thought to be an abnormally folded isoform (PrPSc) of the cellular prion protein (PrPC) and it is further thought that the accumulation of the misfolded prion protein leads to disease [1].
What kind of thoughts?
"In my own work at universities I have been much struck by the paralysis of thought induced in pupils by the aimless accumulation of precise knowledge, inert and un-utilized.
It was long thought that aging is caused by accumulation of random molecular damage and wear and tear.
I reckon these thoughts – that everyone has just through an accumulation of life – will make us sit down to tell a story without us even knowing why.
In this line of thought, platelet accumulation has been identified in the brain microvasculature of patients with CM, suggesting that as in experimental models, they could be pathogenic in the neurological syndrome [11].
As she survives the night in the field, her thoughts wander across a span of memories that are the accumulation of a lifetime.
As Suttie noted: '… it is glaringly obvious that the elaboration and accumulation of tradition and the devising of new ways of training and applying thought are quite independent of cerebral evolution' (1924: 144).
A consensus about facts prevailed in the Watergate era of journalism and popular thought, along with a kind of commonsense faith that the accumulation of facts would yield something like the truth.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com