Sentence examples for accumulation of substrate from inspiring English sources

No significant accumulation of substrate was measured in control vesicles (Fig. 1b).

Deficiency of GCase activity results in accumulation of substrate in the lysosomes of several tissues, including brain.

Whereas the traditional blood glucose measurements rely on the accumulation of substrate in circulation, the breath test is a more direct measure of intracellular glucose metabolism.

Less accumulation of substrate for AMP deaminase or specific inactivation of AMP deaminase both could explain stabilization of the adenine nucleotide pool and reduced ammonia production [ 27].

The significant increase of QRS duration in the Late Group could be due to a further accumulation of substrate in myocardial cells.

ATP-binding cassette (ABC) transmembrane proteins evidently decrease the intracellular accumulation of substrate chemotherapeutic drugs by extruding them against a concentration gradient, thereby inducing drug resistance.

BACKGROUND: Mucopolysaccharidoses are complex lysosomal storage disorders caused by any of eleven different enzyme deficiencies resulting in the accumulation of substrates, mainly glycosaminoglycans (GAGs), in various tissues and biological fluids.

The accumulation of substrates over a certain period of time can be quantified by radio-isotope scintillation counter or LC/MS.

It was observed that there was minimum accumulation of substrates at 30 minutes.

The defects in each of these conditions lead to abnormal intracellular accumulation of substrates that are hepatotoxic and can result in significant clinical liver disease.

CpdA thus leads to ubiquitin-dependent accumulation of substrates for SCFSkp2 E3 ligase activity, such as p27, and consequently induces G1 S cell cycle arrest and apoptosis.