Sentence examples for accumulation of small mutations from inspiring English sources
It is not clear if few genes are responsible of the size effect (e.g., GH, GH-BP, IGF1) or if the reduced size results from the accumulation of small mutations implicating several genes.
Point mutations totalled 756 (52% of small mutations) with 726 (50%) nonsense mutations and 30 (2%) missense mutations.
Point mutations totalled 756 (10% of all mutations, 52% of small mutations) with 726 nonsense mutations (10% of all mutations, 50% of small mutations) and three missense mutations (<1% of all mutations, 2% of small mutations).
In contrast, continuous accumulation of small effect mutations results in a gradual change in fitness of lineages and persistent variation in fitness (Tsimring et al., 1996).
Following Neher and Hallatschek (2013), our model assumes: 1) that the population is under persistent directional selection and 2) fitness changes along lineages in small steps through the continuous accumulation of small effect mutations.
Our approach is based on the assumption that evolution proceeds by accumulation of small effect mutations, does not require species specific input and can be applied to any asexual population under persistent selection pressure.
On the other hand, weak selection can drive diversity through the accumulation of small-effect deleterious mutations [ 57], with detrimental overall population fitness effects unless coupled with a sufficient gain of beneficial mutations to counterbalance this effect [ 58].
Therefore, the effect of mutations affecting HP1 on TSE [33], as for squ and zuc mutations, can be correlated to a significant reduction in the accumulation of small RNAs in ovaries produced by the telomeric P-1152 silocusr locus.
