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Some invaders accumulate native pathogens that suppress the establishment and growth of native seedlings (accumulation of native pathogens hypothesis; Eppinga et al. 2006; Mangla et al. 2008).
These technologies allow the introduction of genetic modifications that facilitate the accumulation of native pharmaceutically-active substances, and even the production heterologous recombinant proteins, including human antibodies, lectins and vaccine candidates.
Accumulation of native Lp(a) may enhance the stimulation of ox-Lp(a), a more potent atherogenic lipoprotein, in the vessel wall [ 46].
We detected an accumulation of native α-synuclein protein in the mesencephalon of c-rel−/− mice when compared with wild-type animals, but no significant change in the protein content of other brain regions (cortex, striatum and hippocampus) (Fig. 4M).
To limit buildup of nonspecific signals (noise) during intercellular communication, it is reasonable to assume a model where fatty acid biosynthesis could be modulated to favor accumulation of native acyl-ACPs.
Intriguingly, increased accumulation of native extracellular HA [ 118] such as what occurs during repair of embryonic tissues [ 140, 141] or disruption of HA:RHAMM CD44 [ 106] complexes in wounds can negatively regulate these signaling pathways so that myofibroblast differentiation is reduced and, conversely, reepithelialization is promoted.
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RNA catalysis can be used to track accumulation of the native RNA specifically and quantitatively, readily distinguishing the native structure from intermediates that resemble it and may not be differentiated by other approaches.
In C. glutamicum wild type, overexpression of sigA led to 2-fold increased accumulation of the native carotenoid decaprenoxanthin in the stationary growth phase.
TdPI unfolds through a major accumulation of the native three-disulfide species IIIb and the subsequent formation of two-disulfide and one-disulfide intermediates.
Addition of pure Unc45bFlag or the Unc45bFlag/Hsp90 complex dramatically enhances the accumulation of the native conformation by conversion of the unfolded protein to the compact folded conformation.
While the liver showed negligible amounts of endostatins, lung tissues had significant accumulation of both native and mutant endostatin.
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