The phrase "accumulation of issues" is correct and usable in written English.
It can be used to describe a situation where multiple problems or concerns have built up over time.
Example: "The accumulation of issues in the project led to significant delays and budget overruns."
Alternatives: "build-up of problems" or "collection of concerns."
"The accumulation of the issues of the past have all come to a head at one time, and that's hard to handle".
However, a number of issues concerning C60 accumulation by cancer cells of different types and biochemical mechanisms of its photocytotoxic effects remain still open.
To partly overcome this issue, accumulation of cAMP was used as an indicator of βAR signaling, which validated miR-30 targeting.
Clinical issue Accumulation of the neuronal protein α-synuclein (aSyn) is associated with multiple neurodegenerative disease processes, including Parkinson's disease.
Spontaneous heating and fire, accumulation of poisonous gases, severe stability issues leading to unsafe workings and environmental hazards are the major problems associated with the developed coal pillars.
Sedentary groups encounter issues such as accumulation of wastes and transmission of epidemic diseases (Armelagos et al. 2005), issues that increase with population size.
The issue of accumulation of error in the PSL method as against the fourth order Runge-Kutta scheme is also described numerically through an example of a first order non-linear equation having closed form solution.
Though the main issues on the interpretation of the statement indicate that "Iran will continue its safeguarded R&D practices, including its current enrichment R&D practices which are not designed for accumulation of the enriched uranium," the issue will likely be discussed much later, in the future round of nuclear negotiations.
Consequently, in her performances, the natural landscape is often invoked as a stage to address such issues as "the accumulation of goods, luxurious lifestyles, socio-economic changes, and cultural development".
Beyond the mental impact of the disorder, the accumulation of clutter can create a health issue.
