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Specifically, Coulumb et al. state that the protein interaction dataset from the Database of Interacting Proteins (DIP), which we used in this analysis, is biased towards essential genes due to the accumulation of interactions from small scale experiments which are partial towards essential genes.
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However, this rapid accumulation of interaction data makes it difficult for scientists to keep track of all available information and data sources.
First, there's Henri, seen but not seen, a man we know through only his movements, which are both inexplicable and mundane, a loose accumulation of random interactions that add up to a life.
Traditionally, the snowball effect for hybrid incompatibilities has been interpreted as a product of the nonlinear accumulation of epistatic interactions that are expected to result from a linear gene substitution process.
A previous study using BiFC has demonstrated an accumulation of Smad2 Smad4 interaction in marginal zone cells of vegetal hemisphere in a subcellular level [16].
And the plural form of "interaction" means that we all develop based not on one Hollywood-style moment, but the patient, incremental accumulation of positive, humanizing interactions.
Therefore, we hypothesize our data reflect accumulation of otherwise reversible interactions between wt Httex1 monomers.
Theory predicts that one outcome of directional selection for competitive fitness traits is the accumulation of nonlinear intergenomic interactions in the population [7], and we have shown that this is plausible.
One group of authors suggested that passive hepatic congestion, accumulation of metabolites, and/or interactions with multiple medications used in the ICU may justify lower dose requirements [ 17].
In order to test if this network did not just represent a random accumulation of gene-gene interactions, 10 random networks were built and compared with the original growth network.
The accumulation of large-scale interaction data on multiple organisms, such as protein-protein and protein-DNA interactions, requires novel computational techniques that will be able to analyze these data together with information collected through other means.
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CEO of Professional Science Editing for Scientists @ prosciediting.com