The phrase "accumulation of effects" is correct and usable in written English.
It can be used when discussing the cumulative impact or results of various factors or actions over time.
Example: "The accumulation of effects from climate change is becoming increasingly evident in our environment."
Alternatives: "cumulative impact" or "build-up of effects".
On one hand it reflects the accumulation of effects originating from the genome and the environment and may inform on a number of ongoing processes relevant to disease.
It will also be important to go beyond simply documenting the accumulation of effects across generations and conduct studies that will provide more direct information on the genetic or epigenetic basis responsible for the differences between hatchery and wild salmon.
DNA methylation profiles that determine tumor aggressiveness and patient outcome may become established through long-term accumulation of effects resulting from H.pylori infection, subsequent chronic active gastritis, atrophic gastritis and intestinal metaplasia.
This is probably due to the non-linearity of the mortality mechanism and the accumulation of effects over time due to changes in the age structure of the worm population.
Special conditions were required for this scenario to prevent accumulation of effects throughout a season, in order to ensure equivalent test conditions between the mechanisms at the end of the season, and also because the effect α of the A allele depends on the frequency of the B allele in worms.
Safingol and a myristoylated PKC pseudosubstrate peptide have been shown to inhibit PKC and potentiate drug accumulation independently of effects on P-glycoprotein [ 31- 33].
It is negative in the beginning, then turns positive, and finally converges to 0. The most recent spikes have inhibitory effects, neutralized later on by the accumulation of excitatory effects, resulting in delaying the immediate formation of a new spike after a spike, preventing short ISIs, which models the refractory period.
In this case, it is not the accumulation of such effects but one major hot event that leads to cancer.
As described above, the accumulation of slight effects from HBc binding to many gene promoters may produce sizeable effects on host cellular functions, possibly increasing a cell's susceptibility to harmful factors, such as carcinogens [ 39].
As in any non-linear oscillator, we would expect that the phase effect of a large number of IPSPs would be a complex non-linear accumulation of the effects of the individual IPSPs.
It is of course the accumulation of these effects that determines the overall stability of the structure (Table 1).
