Sentence examples for accumulation of dump from inspiring English sources

Inhibition of TS in tissues leads to intracellular accumulation of dUMP and subsequent efflux of deoxyuridine (dUrd) into the circulation.

As an analog of the THF cofactor, it cannot be incorporated into DNA, and cellular accumulation of dUMP does not result in resistance to raltitrexed.

101 Inhibition of TYMS leads to intracellular accumulation of dUMP and subsequent efflux of deoxyuridine (dUrd) into the circulation, which can be used as a pharmacodynamic marker of in vivo TYMS inhibition following administration of pemetrexed.

Pemetrexed, an antifolate, inhibits several key folate-dependent enzymes in the thymidine and purine biosynthetic pathways, leading to the accumulation of dUMP and the misincorporation of uracil into DNA.

Such a scenario would be expected to result in an accumulation of dUMP due to a lack of methylation to dTMP, while at the same time result in the sustainment of dTTP pools due to salvage.

Accumulation of dUMP occurs as a direct consequence of TS inhibition and also as a result of increased activity of other enzymes, including ribonucleotide reductase (RR) and deoxycytidylate (dCMP) deaminase (Maybaum et al, 1981).

In minimal medium supplemented with amino acids and purine, cells cannot utilize exogenous thymine or thymidine like in LB. dTTP depletion during thymine starvation induces the ribonucleoside-diphosphate reductases, which increases flux through the dTTP biosynthetic pathway and causes an accumulation of dCTP and dUMP [ 45, 46].

The pH and spoil texture, amount of precipitation, litter accumulation and colonisation of dumps by plants and soil biota were probably important factors for different development of nematode assemblages in the regions compared.

Nests mounds were excavated in the area with the greatest and freshest digging activity of the ants (greatest accumulation of fresh soil excavate dumped outside the nest by the ants), as fungus gardens could be found predictably at a depth of 20 100 cm in this area.

However, a large amount of this waste is still dumped every year [ 9], which causes both economic and environmental problems such as high transportation cost, lack of dumping site, and accumulation of high organic content material [ 10].

R90 also hydrogen bonds to the C4 oxygen of dUMP.