The phrase "accumulation of difficulties" is correct and usable in written English.
It can be used to describe a situation where multiple challenges or problems have built up over time.
Example: "The project faced an accumulation of difficulties that hindered its progress and ultimately led to delays."
Alternatives: "build-up of challenges" or "gathering of obstacles".
This task is challenging due to the accumulation of a number of difficulties like the complexity of the underlying physics and the constraints in the admissible sensor locations and their number.
However, the viruses for single target cell have slower decay rate than that for two target cells, indicating that multi-target cells contribute to slowing down the accumulation of virion and increase the difficulties of treatment.
The loss of force-producing myocytes may underlie contractile dysfunction whereas the accumulation of interstitial collagen might produce difficulties with passive stretch of myocardium during diastole thereby compromising ventricular relaxation in DCM [ 31, 33].
Introduction Prolonged use of intravenous (IV) drugs for intensive care unit (ICU) sedation is associated with accumulation and difficulty of control.
"One possibility we're looking at is that there was something about the accumulation of questions which caused greater difficulty than the individual questions," Mr. Kadamus said.
The electrical conduction of their heart can even be altered, resulting in the accumulation of fluid in the lungs and difficulty breathing.
Other potential lead-ins to climate change include specified teaching about ecosystems, the accumulation of toxic materials in natural life, and the difficulty for some species in adapting to changes in their environment.
Besides individual deficits, combinations of deficits can play a role; the gifted/dyslexic group might show accumulation of risk factors for the development of severe literacy difficulties.
Current limitations in the treatment of GBM involve obstacles towards achieving complete tumor resection, difficulties in penetrating the blood brain barrier (BBB), insufficient accumulation of therapeutic agents at the site of the tumor, and tumor resistance.
