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The time-course of receptor binding to scaffold elements shows a fast depletion of AMPARs from the ESM, and a concomitant rapid accumulation of bound AMPARs in the PSD as AMPARs diffuse into the PSD area and bind to available scaffold anchors.
Antibody and antigen complexes are also recycled through the FcRn pathway and can result in accumulation of bound antigens in the circulation and extension of the half-life of the antigens (Igawa et al., 2013).
We suggest that the very high levels of reductase in the above listed, probably normoxic, tissues contribute significantly to the accumulation of bound reactive MISO metabolite(s).
Use of cellulase recovered from lignocellulosic residue for subsequent rounds of hydrolysis have been shown to experience reduced activity, which has been attributed to accumulation of bound lignin after each successive round of hydrolysis [ 154, 163].
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Accompanied with these symptoms is an accumulation of ubiquitin bound αS within diseased cells [2].
It has been reported that accumulation of nanoparticle bound drugs are 45 250 times higher in the site of tumors compared to other vital organs such as the liver, kidney, lung, spleen, or heart [34].
After the formation of AGEs, the accumulation of AGEs bound to proteins is dependent on the half-life of these proteins.
As a result, the expression of VviUGT85A1L1 was probably related to differential accumulation of these bound compounds across the two regions.
We propose a model where the accumulation of constitutively bound CHMP2B on endosomes may render them incapable of fusion with lysosomes.
Accumulation of ubiquitin bound proteins and proapoptotic Bax, a proteasome target, were observed up to 48 hours after treatment, suggesting durable proteasome inhibition by carfilzomib.
Transmission electron microscopy identified the intracellular peri-nuclear accumulation of membrane bound organelles containing amorphous, electron dense material - phenotypic features suggestive of lipofuscin granules, at magnifications of both 7450X and 22300X in both normal and glaucomatous LC cells.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com