The phrase "accumulation of a large" is correct and usable in written English.
It can be used when discussing the gathering or collection of a significant quantity of something, often in a context related to data, resources, or experiences.
Example: "The accumulation of a large amount of data over time can lead to more accurate predictions in research."
Alternatives: "collection of a significant" or "gathering of a substantial".
Implicit in designation of the well-plugged category is a common association of summit crater size 2.5 5 km with eruptions of VEI 6, repose periods in hundreds of years, wide pyroclastic aprons and, from Pinatubo, accumulation of a large mass of gas, far in excess of saturation, probably accumulated over centuries.
This production is the basis of wood formation and is thus essential for the accumulation of a large proportion of terrestrial biomass.
On a more global scale, SF-1 knockdown affects the accumulation of a large number of transcripts, most of which are not recognizably involved in steroid hormone biosynthesis.
Inhibition of nuclear import is predicted to result in the cytoplasmic accumulation of a large number of nuclear proteins that could have functions in viral translation, RNA synthesis, packaging, or assembly.
Shepherdy and nomadic animal breeding, which determined the social and economic organization and the way of life of some peoples to a great extent, appeared at later stages of human development, after the accumulation of a large number of domestic animals.
In many instances temporary protection from fire has resulted in the accumulation of a large mass of flammable vegetation that, when burning, makes a hot fire, which kills the overstory trees and many species that normally survived the more frequent and less-severe fires of the past.
Thus, a highly stable enzyme can tolerate the accumulation of a larger number of destabilizing mutations.
Obviously, reduction of disulfide bonds facilitated unfolding of the protein, which enabled accumulation of a larger number of charges on the surface of the protein.
In contrast, CYB3 and CYB1 partitions are much less informative than GHR3 despite higher evolutionary rates that would have allowed the accumulation of a larger number of synapomorphies.
The latter will only become apparent after a longer period of implementation in the pilot provinces and districts, and the accumulation of a larger body of programme data and operational results.
As expected, the Dn/Ds values in the human branch tended to be much larger in the accelerated gene set than in the complete gene set (Wilcoxon test p < 10-5), reflectheg the accumulation of a larger number of fixed non-synonymous substitutions in the former set.
