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Concomitant with the reduction in α-syn accumulation, analysis of the dendritic marker MAP2 showed an increase in the percent area of the neuropil covered by dendrites in α-syn tg mice that received the LV-Atg7 (Figure 9O U), supporting the possibility that the reduction of α-syn accumulation in the LV-Atg7-treated animals ameliorated the structural damage to neurons of α-syn tg mice.
Northern blot mRNA accumulation analysis of selected genes expressed under various kinds of oxidative stress are shown in Figure 2. MNorthern = log2 optical densitystress-exposed*optical densitycontrol-1) values were calculated for each exposure time and each stress-inducing agent concentration tested.
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