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In recent years, there has been an accumulating understanding of their role as signaling molecules (Atashi et al., 2015).
This accumulating understanding of the mechanism of action of estrogen led ultimately to the design of antiestrogenic agents that work by virtue of their interaction with the ER; these drugs have come to be known as selective estrogen receptor modulators (SERMs).
Moreover, underexpression of LKB1 in ccRCC complements the accumulating understanding that kidney cancer is a disease of cell metabolism with AMPK underactivation as the common molecular hub which was only demonstrated for other less common subtypes of RCC until now (Linehan et al, 2010).
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As specificity engineering cases accumulate, understanding the mechanisms of the specificity determination will increase.
Recognizing the useful knowledge held by health system actors allows health policy and systems researchers to access a greater breadth of such knowledge, including practical, moral, and cultural wisdom drawn from lived experiences and accumulated understanding of health system realities [ 20] (Case studies 1 to 3).
Ultimately, it will be ideal for a knowledge-based automated composite design expert system be established, which would include accumulated understandings and models developed in this area.
Accumulated understanding derived from murine systems is increasingly becoming more translatable to human immunology and disease pathology.
In particular I am concerned to show how I tried to help SFL evolve, accumulating previous understandings into a model with additional theoretical architecture taking descriptive responsibility for a wider range of linguistic data.
These researchers also highlight the important element of time for accumulating shared understandings.
Although introductory courses by their very nature aim to build on the students' previously accumulated knowledge, understanding and experience, especially the unstructured kind based on life experience, the students in this study were able to develop this skill with very minimal instruction, when compared to the normal length of introductory medical ethics courses [ 25].
With the development of sequencing technology, many plants such as Arabidopsis, rice, maize and sorghum have had their complete genome sequence [ 20- 23], which has accelerated the research on functional genomics and accumulated the understanding of mechanisms that underlie plant growth and development.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com