The phrase "accumulating trials" is correct and usable in written English.
It can be used to describe the process of gathering or experiencing multiple challenges or tests over time.
Example: "The scientist faced accumulating trials in her research, but she remained determined to find a solution."
Alternatives: "growing challenges" or "increasing difficulties".
17 TSA was also performed to quantify the reliability of data in meta-analysis adjusting significance levels for sparse data and multiple testing on accumulating trials.
Trial sequential analysis (TSA) is performed to quantify the reliability of data in meta-analysis adjusting significance levels for sparse data and multiple testing on accumulating trials.
Another purpose of the study was to perform trial sequential analysis (TSA) to examine the changes over time and whether further studies need to be conducted, by adjusting significance levels for sparse data and multiple testing on accumulating trials.
Observational evidence will be down-weighted by a power of α which takes values from 0 to 1. Trial sequential analysis will be performed to quantify the reliability of data in meta-analysis adjusting significance levels for sparse data and multiple testing on accumulating trials.
Adaptive designs learn from accumulating trial data in real time and apply this knowledge to optimize subsequent study execution.
Interim analysis of accumulating trial data is important to protect participant safety during randomized controlled trials (RCTs).
We also suggest an approach to assessing maturity (readiness for analysis) of accumulating trial data according to the RMST method.
A third of protocols for industry initiated randomised trials receiving Danish ethics approval in 1994-95 sthatd thet the sponsor had access to accumulating trial data, which can introduce potential bias due to competing interests.
Though our review uniquely aimed to determine if and when sufficient evidence for exercise interventions had been accrued, repeated meta-analysis with accumulating trial data can lead to false positive findings (random errors) if multiple testing is not accounted for.
Alternatively, we can invert eqn. (8) and calculate the power, ωcurr, for the current data under the design assumptions as (10) ω curr = Φ Δ 2 var Δ ^ - z 1 - α / 2 Sometimes, for reasons of confidentiality of the accumulating trial data, it is desirable to estimate data maturity or power ignoring information on possible treatment effects.
At the level of the systematic review, we will extract data on review ID, author, year of publication and accumulated trial size combined in the meta-analysis (ie, NTotal, NI and NC).
