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Organisms integrate multiple stressors physiologically, accumulating factors that limit oxygen metabolism and aerobic scope (Pörtner et al. 2001; Pörtner and Farrell 2008; Anttila et al. 2013).
However, we believe we have identified a pattern of expression of developmentally important networks (e.g., WNT and Notch signaling networks) which supports the hypothesis that converging and accumulating factors disrupt regulatory networks controlling heart development during embryological development ultimately leading to tetralogy of Fallot.
Rather, decision making was presented as a blend of accumulating factors used to discount certain possibilities and point in the direction of others.
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Introduction: Nowadays, opposite to ancient times, the feeling of caring only for patients accumulating frailty factors wins ICU physicians.
During autophagy, PI3P is essential for accumulating regulatory factors to the site of autophagosome formation.
More evidence is accumulating that factors in the home environment play an important role in sensitizing children to asthma and triggering attacks.
First, a broader perspective may be appropriate on the age of onset in type 2 diabetes to encompass accumulating risk factors and preclinical stages of disease throughout life.
Strains with defective restriction modification systems acquire MGEs at higher frequencies and have greater potential to become "superbugs" by accumulating virulence factors and resistance genes (Corvaglia et al. 2010; Sung and Lindsay 2007; Waldron and Lindsay 2006).
Soluble form of syndecan-1 can accumulate survival factors within the microenvironment, representing a sort of sponge for these factors around the tumor cells [ 36].
A substantial body of evidence has accumulated linking factors that are increasingly endemic in EDs, such as high workloads [18], overcrowding and access block [19], to negative outcomes for all ED patients.
Moreover, teratomas have been observed in transplants of as few as 2 ESCs [16], which is presumably not a high enough cell number to accumulate autocrine factors.
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CEO of Professional Science Editing for Scientists @ prosciediting.com