Sentence examples similar to accumulated trial data from inspiring English sources

Adaptive designs learn from accumulating trial data in real time and apply this knowledge to optimize subsequent study execution.

Interim analysis of accumulating trial data is important to protect participant safety during randomized controlled trials (RCTs).

We also suggest an approach to assessing maturity (readiness for analysis) of accumulating trial data according to the RMST method.

A third of protocols for industry initiated randomised trials receiving Danish ethics approval in 1994-95 sthatd thet the sponsor had access to accumulating trial data, which can introduce potential bias due to competing interests.

Though our review uniquely aimed to determine if and when sufficient evidence for exercise interventions had been accrued, repeated meta-analysis with accumulating trial data can lead to false positive findings (random errors) if multiple testing is not accounted for.

Alternatively, we can invert eqn. (8) and calculate the power, ωcurr, for the current data under the design assumptions as (10) ω curr = Φ Δ 2 var Δ ^ - z 1 - α / 2 Sometimes, for reasons of confidentiality of the accumulating trial data, it is desirable to estimate data maturity or power ignoring information on possible treatment effects.

The objective is to use the accumulating clinical trial data generated to identify suitable combinations of effective targeted treatment and linked predictive biomarker to take forward for testing in an enriched randomised phase III trial.

Trial sequential analysis (TSA) is performed to quantify the reliability of data in meta-analysis adjusting significance levels for sparse data and multiple testing on accumulating trials.

17 TSA was also performed to quantify the reliability of data in meta-analysis adjusting significance levels for sparse data and multiple testing on accumulating trials.

Another purpose of the study was to perform trial sequential analysis (TSA) to examine the changes over time and whether further studies need to be conducted, by adjusting significance levels for sparse data and multiple testing on accumulating trials.

One benefit was the reduction in variance for the D2 index as the trial data accumulated.