Sentence examples for accumulated toxicity from inspiring English sources

Most patients have tolerated repeat courses of treatment without further accumulated toxicity.

DNMT inhibitors as relapse therapy and maintenance after HSCT Patients with leukaemic relapse after stem cell transplantation have a very poor prognosis, and treatment options are limited because of accumulated toxicity and impaired organ function.

> -wrap-foot>> -wrap-foot> DNMT inhibitors as relapse therapy and maintenance after HSCT Patients with leukaemic relapse after stem cell transplantation have a very poor prognosis, and treatment options are limited because of accumulated toxicity and impaired organ function.

Experiments using a significantly longer Gdm+ treatment of 30 min yielded measurable toxicity, but we did not detect accumulated toxicity with prolonged, regular use of 5 min Gdm-Cl treatments over consecutive asexual cycles (not shown).

Oxaliplatin was discontinued in 25% of patients, who then continued to receive gemcitabine and panitumumab, and it is possible that such an approach, utilising the two agents with little accumulated toxicity as maintenance therapy enabled a relatively long PFS.

(Sara, 34 year old Muslim woman) The main reasons for stopping or altering the dose were: side-effects (such as headaches, loss of short-term memory, weight gain, impotence, stomach problems and general tiredness); fear of accumulated toxicity in the body; fear of harm to the unborn baby during pregnancy.

This difference possibly means that VEGF is helpful at preventing the accumulating toxicity that arises from neurodegenerative processes that begin before motor neuron death or symptom onset (Dal Canto and Gurney, 1995; Bendotti et al., 2001).

This is likely to be related to tumour progression, although the impact on HRQoL of factors such as unresolved adverse events, accumulating toxicity and emotional response cannot be ruled out.

Our numerical results show that there are fundamental differences between protocols designed to minimize total CPA exposure time in tissues and protocols designed to minimize accumulated CPA toxicity, and that "one size fits all" stepwise approaches are predicted to be more toxic and take considerably longer than needed.

Left ventricular size may merely be reflective of the accumulated cardiovascular toxicity of end-stage renal disease and regression of LVM may indicate an attenuation of these effects.

A related health concern, which was the principal reason for delaying ART in developed countries, is the risk of accumulated drug toxicities.