Instead of blindly accumulating site mutations, a better strategy may be the generation of chimeric connexins where a loop domain of one connexin can be substituted for another.
Ag AgX(X = Cl, Br)@TiO2 nanoparticle-aggregated spheres (NPAS) have been designed as a photocatalyst, in which AgX works as light harvester, Ag conducts as electron trapping and accumulating site, and TiO2 acts as electron collecting and photocatalytic site.
Therefore, the increase in coverage obtained when accumulating site data from all relatives across a superfamily, is due to the fact that some of the functional subfamilies must exploit different sites on the domain surface.
Crayfish hepatopancreas was confirmed to be the primary accumulating site for the majority of metals (Cu > Zn > Ni > Cd > Cr), while Hg and Cr were concentrated in abdominal muscle, and Al and Pb were concentrated in gill.
Previously Lan et al. reported that GFP-WRN accumulated at sites of DSBs and the fluorescence at the sites reached a plateau within 3 min [ 22].
Bcl-2 pro-apoptotic family members are heavily accumulated at sites of mitochondrial fission during apoptosis.
In the cortexillin double-null cells, actin strongly accumulated at sites of negative curvature (see Additional file 6).
These cells later accumulated at sites in the lung where the bacteria reside, and ultimately protected against M. tuberculosis infection.
Figure 6B shows that compared with untreated cells, glioma cells exposed to compound 4 accumulated AP sites confirming target inhibition in vivo.
The resulting images suggested that dT-QX accumulated at sites other than the mitochondria, although there were some overlaps of dT-QX in the mitochondria.
For example, micrometer-sized carriers composed of polymeric nanoparticles that dissociate under high shear stress accumulate in site of vascular stenosis.
