The phrase "accumulated fragmented" is not correct as it stands and lacks clarity in written English.
It may be used in contexts discussing the collection of disjointed or incomplete pieces of information or data, but it needs to be rephrased for better understanding.
Example: "The research revealed accumulated fragmented data that made it difficult to draw clear conclusions."
Alternatives: "gathered disjointed" or "collected incomplete".
PINK1-deficient dopaminergic neurons accumulate fragmented mitochondria and increased mitochondrial O2− [ 242].
In support of this idea, a recent study described that MLIV fibroblasts accumulate fragmented mitochondria and exhibit increased sensitivity to apoptosis induced by Ca2+-mobilizing agonists (41).
Following EphB4 knockdown, cells were unable to enter the G0 phase of the cell cycle and began to accumulate fragmented nucleosomes in the cytoplasm consistent with apoptosis.
We propose that instructing freshman in the process of science may enable more students to excel in their disciplines, particularly biology, because of its ever accumulating and fragmented content.
In these models, damaged and fragmented mitochondria accumulated within cells and displayed a reduced capacity to buffer calcium, leading to increased susceptibility to cell death (Jennings et al., 2006; Settembre et al., 2008a).
RNA-Seq may also have trouble to detect isoforms and their exact start and end sites, as the cDNA is randomly fragmented, and accumulated from all isoforms within a given genomic loci [ 21].
However, in cells containing expanded polyglutamine repeats, similar to the autophagy-defective Atg5 KO MEFs (Appendix Fig S3B), mitochondrial marker was found also in the lysosomal fractions (Fig 3A), suggesting that lighter (empty, damaged, and fragmented) mitochondria accumulated and co-fractionated with upper lysosome-enriched fractions.
In addition, swi3Δ cells accumulate significantly more fragmented DNA during recovery when compared to rad3Δ cells.
Foreign (nonstorage proteins) and genetically modified storage proteins tend to be proteolytically unstable in PSVs and consequently often fail to accumulate or are fragmented when expressed in plants [6], [7].
