The phrase "accumulated disability" is correct and usable in written English.
It can be used in contexts discussing the gradual build-up of disabilities over time, often in medical or psychological discussions.
Example: "The patient's accumulated disability over the years has significantly impacted their quality of life."
Alternatives: "cumulative disability" or "progressive disability".
The risk of accumulating disability increased proportionally with number of attacks and inversely with time between the first and the second attack.
Patients at higher risk of accumulating disability from disease onset had more Years 1 and 2 relapses, shorter relapsing remitting phases, yet fewer total Year 3-secondary progression attacks.
Some patients steadily accumulate disability with no recovery from the very onset of MS; this is known as primary progressive MS (PPMS).
Nonetheless, the actual existence of "truly" BMS is still a matter of debate, since several reports describe BMS patients accumulating disability and even converting to SP in a later phase of the disease [ 2, 3].
> -wrap-foot> The risk of accumulating disability from disease onset was confirmed to increase proportionally with Years 1 and 2 relapse frequency and inversely with numbers experienced after Year 2; these effects are independent and were unchanged after multivariate analysis.
Chronic relapsing experimental autoimmune encephalomyelitis (crEAE) induced in the Biozzi ABH mouse using spinal cord homogenate recapitulates many of the clinical and pathological features of MS including RR episodes and secondary progression, which is associated with accumulating disability along with inflammatory mediated demyelination, neurodegeneration and remyelination [ 11- 16].
Pediatric MS now makes up between22 percent and 5 percent of the population of those with MS. According to the National MS Society, the earlier the onset, the more likely one is to accumulate significant disability at an earlier age compared to those with adult onset of MS. It appears to be creeping into the lives of a much younger population.
The risk of accumulating severe disability decreased proportionately to relapses experienced in Year 3-secondary progression.
In summary, we found that ever-smokers with multiple sclerosis accumulate more disability over a shorter period of time and suffer from more severe disease than never-smokers.
Moreover, tumor necrosis factor inhibitors plus methotrexate significantly retard joint damage, even in patients who do not respond well clinically, thus reducing the propensity to accumulate irreversible disability with active disease.
