The phrase "accumulated defects" is correct and usable in written English.
It can be used in contexts related to quality control, manufacturing, software development, or any field where issues or errors have built up over time.
Example: "The accumulated defects in the product line have led to a significant increase in customer complaints."
Alternatives: "cumulative errors" or "gathered flaws".
The predicted consequence of defective spliceosome assembly is that variable mRNAs become limiting at different times, and the cells eventually die from accumulated defects in multiple processes.
This defect is conceivably more pronounced in mice over one year of age owing to both the natural aging processes and TGF-β1-induced accumulated defects in epithelial wall integrity.
2) HSCs are capable of clearing the accumulated defects to reverse cellular senescence.
The aging process represents progressive changes in a cell or an organism which culminate in death due to accumulated defects in function leading to system failure [ 1].
Both the accumulated defect states and nonradiative recombination rates were reduced, and these correlations were confirmed systematically by diffraction, absorption, and time-resolved photoluminescence.
The simple annealing process diminished the accumulated defect states within the InP/ZnS core/shell QDs and therefore decreased the non-radiative recombination [44].
The simple annealing process diminished the accumulated defect states within the nanoparticles and thereby reduced the nonradiative recombination, which was confirmed by diffraction, absorption, and time-resolved photoluminescence.
The accumulated defect such as the a/2〈1 1 2〉 L10 type dislocation is the main reason for the attenuation of the elastocaloric effect in a fatigue test up to 3000 cycles.
Widschwendter, who likens the DNA sequence to the genome's "hardware" and epigenetic changes to its "software," says that the Esteller team's study supports earlier research suggesting that "as a function of age and environmental exposure, this software accumulates defects" that can cause "age-related cancer and degenerative diseases".
In these mutants, however, the embryos only start to accumulate defects later in embryogenesis, when the nuclear density increases and the spindles start to collide.
The progression of an adenoma to CRC can be attributed to accumulated genetic defects that regulate homeostatic cell behavior.
