In addition, relics of TEs that have accumulated as a consequence of RIP have been described in the N. crassa reference genome derived exclusively from FGSC 2489 (OR74A) (Selker et al. 2003).
Moreover, this low pace activity can be reinforced by the inhibition caused by malonyl-CoA, that could be accumulated as a consequence of decreased FAS expression, since its decrease is faster than that of ACC (the expression of ACC has been reduced to 0.47 with 24-hour treatment, whereas FAS expression was reduced to 0.17 (data not shown).
On the other hand, during manual handling, tears and missing pieces might gradually accumulate as a consequence of reduced mechanical strength.
In P. oceanica, malate has previously been shown to accumulate as a consequence of anoxic conditions [ 54].
In the context of acute renal failure in sepsis, it is clear that metabolic compounds partly accumulate as a consequence of the loss of renal function.
Oxidative and DNA damage, which accumulate as a consequence of proliferation or from a defense response against pathogens (Lambeth 2007), eventually compromises regenerative ability, resulting in reduced fitness (Apel and Hirt 2004).
Genes from both rice (OsMADS50) and ryegrass (LpMADS1, LpMADS2, LpMADS3) that share sequence similarity with AtSOC1, and may be functional equivalents of it, are also reported to accumulate as a consequence of vernalisation [ 40, 41].
Our results are consistent with the hypothesis that transposon RNAs frequently originate within genomic TE units and do not primarily accumulate as a consequence of random 'read-through' from gene promoters.
The nucleic acids that may accumulate as a consequence of impaired RNase H2 function are yet to be defined, and although RNase H2 enzyme activity has been studied for more than 40 years (Stein and Hausen, 1969), its cellular functions are poorly understood.
If so, then there are comparatively fewer instances when mechanical degradation can accumulate, and as a consequence, even degraded objects do not become unfit and only ~10%% of acidic paper will reach the fitness threshold, with the rest of the collection remaining fit for use.
As species diverge, satDNAs accumulate changes as a consequence of mutations and turnover mechanisms in separate lineages generating species-specific satDNA arrays (Dover 1986).
