To account for variations in editions' age, number of active contributors, and growth rates, we selected the time frame such that (1) to ensure a sufficient amount of editions existed in the beginning of the observation; (2) to allow enough time for each edition to accumulate concepts.
Since we have spent most of our lives being taught to accumulate concepts categorizing what we perceive, this invitation is also a challenge.
In general, fluid intelligence (the ability to manipulate abstract concepts) decreases with age while crystallized intelligence (the use of the accumulated concepts) increases with age.
The discipline of architecture depends on the transmission in space and time of accumulated experiences, concepts, rules, and models.
As experience with multiple clinical trials accumulates, some general concepts seem worth emphasizing.
The role of relaxed purifying selection in functional diversification has been embodied in the neofunctionalization and subfunctionalization concepts whereby duplicates accumulate mutations that either lead to the emergence of new functions or differentially inactivate subfunctions of the ancestral singleton, while the remaining subfunction is maintained or even enhanced [ 11- 17].
The plant based remediation technology is an emerging concept aims to accumulate and translocate metal in plant cells and thus removing metal content in water through several phytoremediation processes, namely, phytoextraction, phytodegradation, rhizofiltration, phytostabilization, and phytovolatilization [ 5, 6].
Here, we accumulate key arguments against the concept that metformin acts in vivo as a "mitochondrial poison" that inhibits complex I of the respiratory chain, which consequently leads to an imbalance in the AMP/ATP ratio (the extremely sensitive indicator of the intracellular energy status, which is the molecular parameter monitored by AMPK) [ 13- 15].
But over time, his concept accumulated accessories, like more housing, movie theaters, maybe even a Chelsea Piers-like sports complex.
The concept that genetic changes accumulate during development and progression of cancer is widely accepted.
An earlier study does not support the concept that PCDD/Fs and DL-PCBs accumulate into liver tissue via the lipid partitioning only.
