Thus, the benefit of treatment in the first 6 months cannot be attributed to combination therapy but rather to a cyclosporine-mediated decrease in renal clearance of the active metabolite, 7-OH methotrexate, thereby increasing its half-life and accruing additional responses.
A two-staged Simon accrual design was adopted with a minimum target activity level (CR+PR) of 20% (Tournigand et al, 2004), with the initial stage accruing 24 response-assessable patients.
This design skews the allocation probabilities which depend on both patients' first observed covariates and sequentially estimated parameters based on the accrued longitudinal responses and covariates.
It is presented a numerical investigation of the head response accruing to blast loads on helmet protective systems.
The dietary protein allowance for older men to maintain lean body mass and muscle strength and to accrue optimal anabolic responses to promyogenic stimuli is poorly characterized.
In addition if a prospective study design had been utilized, time and cost would have made it impossible to accrue 1009 patient responses, which provided the statistical power to evaluate multiple predictor variables each with small effects.
DOI: http://dx.doi.org/10.7554/eLife.04872.018 Actin polymerisation in the vicinity of the ER also altered the dynamics of the ISR in response to gradually accruing ER stress induced by the glycosylation inhibitor tunicamycin.
Though evidence is accruing that MRI may be helpful in early response assessment, this is by no means standardised and is heavily dependent on many factors, not least tumour immunophenotype.
A TGP response will result in more rapid population expansion in stressful habitats compared with a PP response because of the time delay in accruing fitness benefits of adaptive PP.
Accruing new revenue sources by adding security capabilities (for example, monitoring, response) into an existing product/service portfolio.
The accruing evidence suggests that Kupffer cells and T cells mediate the activation of neutrophil inflammatory responses.
