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Thus interpretation of the roles of different inflammasomes in cancer development has to take into account tissue types.
Additionally, our data may suggest that the investigation of drugs in sepsis should take into account tissue measurements of inflammatory pathways and insulin signaling, or other early tissue markers that indicate the severity of sepsis.
Moreover, in order to take into account tissue heterogeneity, a larger sample might be necessary.
Here, we show equivalent dipole source localization results for sources through the brain volume, but using BEM models that cannot take into account tissue anisotropy.
Also, the RIF as calculated here is only a rough estimation since it does not take into account tissue variability, library normalization and possible cloning bias.
Our normalization approach takes into account tissue shrinkage, and we optimized our MRI parameters based on quantitative maps of relaxation parameters (T1/T2*).
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This network can be tuned towards tissue specificity by taking into account tissue-specific gene expression and other characteristics.
Together, these two concepts suggest approaches that could lead to the development of tissue-specific drugs via taking into account tissue-specific alternative splicing in disordered regions that form protein-protein interactions that can be blocked by small molecules.
The wide range of expression observed in the three non-glomerular tissues was expected, as the pooled SAGE-based comparison does not take into account tissue-to-tissue variation in gene expression.
Not only age-related pathological findings were tissue-specific, but the overall age-related changes in the gene expression profiles were also highly tissue-specific, arguing for caution to consider aging as a systemic generic process and take into account tissue-specific aging [ 7- 12, 68- 73].
Gerasimova et al. successfully predicted functional SNPs contributing to asthma, in part by taking into account tissue-specificity of enhancers using epigenetic datasets [ 9]. Paul et al. showed enrichment of SNPs associated with hematological traits within nucleosome depleted regions of hematopoietic cells [ 10].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com