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Dose selection approaches for nonclinical studies of safety assessment for pharmaceuticals should consider the need to demonstrate the full range of the dose response continuum (e.g., NOAEL through a toxic dose), however, should also take into account relevance to human therapeutic doses and incorporate clinical indication- and phase-specific considerations.
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Specifically, we examined how the auditors evaluated the proposed standards on the dimensions of accounting "relevance" and "reliability". The FASB recognizes a trade-off between those two goals and has justified the increased use of fair value accounting by arguing that it increases accounting's relevance.
And there can be no doubt that the Florida Supreme Court was attentive to the terms of the statute and took into account the relevance of 3 U.S.C.
The combination takes into account the relevance of the information provided by each strategy based on the intensity variability.
We demonstrate that an extension of the classic Policy Gradient algorithm that takes into account parameter relevance allows for better solutions when only a few experiments are available.
The objective is to facilitate the dissemination of information between vehicles when they meet each other, taking into account the relevance of the data to the drivers.
The defined PBK models can be used to guide the experimental design of in vitro experiments with flavonoids, especially to better take into account the relevance of metabolism and the contribution of metabolites to the biological activity in humans.
Sadly, the account of relevance that this all depends on is not defensible.
The merger of both theoretical frameworks allows us to focus on rules reflecting descriptive patterns of behaviour, as well as to take into account their relevance to the legal environment in which smart grids are to be realized.
This may be taken into account for relevance estimation of CAMs in smart CAM processing engines: a CAM from a faraway vehicle may be considered more valuable than a CAM from a nearby vehicle.
With the digitalization of mapping, we increasingly have to take into account the relevance of the influence of the instruments being used in the mapping process, as Curry (1998) has pointed out for geo-information systems (GIS).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com