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Hierarchical models have been suggested that specific TFs account for differentiation programs in a multistep way.
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For example, multiple isolated equilibria can account for cell differentiation in biological organisms [27], and many different inter- and intra-cellular processes are represented by limit cycles [28], where probably the most prominent representatives are the circadian rhythms [29], [30].
Thus, the most suitable explanation to account for the differentiation between oneself and another agent, is that it occurs on the basis of non-overlapping areas [13], such as in the IPL.
As an internal control to account for keratinocyte differentiation in response to Ca2+-stimulation, the FLG gene was measured with each cDNA in a separate PCR reaction using intron-spanning primers (forward primer: 5'- GGC TCC TTC AGG CTA CAT TCT A -3', reverse primer: 5'- ATC TGG ATT CTT CAG GAT TTG C -3').
Thus, the pathological features of the entorhinal and transentorhinal regions must not be taken into account for further differentiation of stages V and VI.
Temporal analysis together with the possibility to account for variable differentiation efficiencies can filter out those genes for which the replicated Th0 and Th17 profiles are seemingly similar and thus likely false positives.
ChIP-seq libraries for histone modifications associated with transcriptional activation (H3K4me3) and repression (H3K27me3) were also generated to assess whether epigenetic mechanisms account for the differentiation arrest phenotype in Kasumi-1 cells.
Because translation efficiency of a gene is closely related to its functional importance, the observed functional distributions of orthologous genes with different translation efficiency might account for phenotypic differentiation between A. gossypii and yeast species.
In order to account for population differentiation of multivariate sperm morphology, we performed a canonical discriminant analysis (PROC CANDISC; SAS v. 9.1), which asks if sperm from all populations are morphologically indistinguishable overall.
Both these findings could account for phenotypic differentiation between multicellular A. gossypii and unicellular yeasts, and would shed light on the evolutionary processes that enable pseudohyphal growth in pathogenic yeast species.
Several mechanisms have been proposed to account for this differentiation, including the lack of estrogen-induced synaptic plasticity in the male arcuate nucleus [ 25] and an attenuated distribution of kisspeptin neurons in males [ 26].
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