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This model takes into account cell mortality, non-viable cell accumulation and cell recycling.
The first project has modeled the effects of blood flow on endothelial cells lining arteries, taking into account cell shape change resulting in changes in the cell skeleton which cause consequent chemical changes.
In addition, in view of today's application of probiotics in an increasing variety of food matrixes, process optimization and product design need to take into account cell viability and probiotic function altogether.
The wide range of fluorescent phenotypes and the inability of the average population properties to fully characterize network behavior, indicate the importance of taking into account cell population heterogeneity when designing such a gene-switching network for biotechnological and biomedical applications.
Consequently, this model allows the investigation of drug response taking into account cell heterogeneity.
Equations 1– 5 constitute a full theory for tissue mechanics taking into account cell shape changes.
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Here we applied a novel discrete dynamic modeling approach using three-state logic variables, taking into account cell-to-cell variations on the protein activities and reaction rates, and allowing for simulated population effects.
Basically, the detection involves automated smart thresholds taking into account cells neighborhood, mathematical morphology (watershed-based) segmentation, and several sorting filters in order to discard labeling artifacts and then to reject the cells overlapping too much.
All of them take into account cell-autonomous (cancer-specific) properties and are known as (i) genetic streamlining, (ii) oncogenic shock and (iii) synthetic lethality (SL).
Hence it would be important to explain clearly what the gains achieved by an individual-based framework taking into account cell-mediated infection explicitly are.
Thus, 3-D culture is becoming the model of choice because it provides a simple and easily manipulated system that shows similar architecture to real tissue and takes into account cell-cell and cell-matrix interactions.
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CEO of Professional Science Editing for Scientists @ prosciediting.com