SRSF2 sensitizes hepatocellular cancer cells to the chemotherapeutic drug 5-fluorouracil via upregulation of the proapoptotic splicing form of caspase 2. Accordingly, its repression by microRNA 193a-3p reducesensitivityty of hepatocellular cancer cells to 5-fluorouracil [ 7].
Accordingly, IRF-8 repression in a restrictive myeloid progenitor cell line was partially alleviated upon treatment with histone methyltransferase inhibitors.
Accordingly, estrogen-induced repression of SCD-1 expression in liver and adipose tissue [ 34– 39, 39, 40] has been associated with a down regulation of SREBP-1c expression [ 34].
Accordingly, perturbing the endogenous repression of the BMP signaling cascade by deleting either the inhibitory SMAD6 [ 51] or noggin [ 52] leads to hyperplastic cardiac cushions due to increased cell proliferation.
The RAD51 gene has a well established role in DNA repair through homologous recombination and, accordingly, EZH2-mediated epigenetic repression of RAD51 associates with accumulation of DNA damage and chromosome abnormalities.
Accordingly, this same chain reaction de-repression of inhibition, followed by calcification—can be enhanced severeaction de-repressionof of small amounts of calcinhibitionosphate (0.3–1 mM).
Accordingly, insertion of 2-gene repression-based synthetic loops in bacteria indeed may give rise to bistable dynamics [ 8], whereas 3-gene repression-based synthetic loops inserted into living bacteria are capable of spontaneous oscillations with a very long period (more than 2.5 hours, i.e. twice the cell doubling time) [ 9].
Accordingly, a recent study proposed that repression by Ssn6-Tup1 involves masking of the activation domain of activators thereby blocking the recruitment of coactivators such as SWI/SNF, SAGA, and mediator complexes (Wong and Struhl 2011).
Accordingly, the authors conclude that androgen-repression of miR-125b promotes androgen-dependent growth of prostate cancer cell lines through the de-repression of IGF1R.
Accordingly, addition of PDZ ligand in trans relieved repression, increasing Cdc42 exchange activity.
