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The observed effects in rats according to dose and frequency are shown in detail in Table 25.
Based on this work, the limits of HT and HTO release amount for arbitrary accidents were proposed for the fusion reactor according to dose limit of ITER.
Methods Sprague Dawley rats were randomized into three groups according to dose and route of delivery of chemotherapy (10 mg/kg: intravenous; 10 mg/kg: intraperitoneal; 100 mg/kg: intraperitoneal).
PLS analysis was also used to reveal the correlation pattern between the two blocks of data as well as the within the two blocks according to dose, time and the interaction dose×time.
The population TACs were generated by averaging the baseline [11C]--PHNO PET data after motion correction over the eight healthy subjects and were scaled according to dose and subject weight.
It would seem that the three compounds have the same or overlapping targets, since the phenotypes they invoke are essentially indistinguishable according to dose response experiments.
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Drug concentrations were optimized for each compound according to dose-response analyses and half maximum inhibition of concentration IC50 (mean time-dependant IC50).
Effective dose (ED, mSv) was calculated according to dose-length product (DLP, mGy·cm) and the tissue weighting factor k (mSv × mGy−1 × cm−1) commended by the European Commission (0.0021) [ 16].
Dose was optimised according to dose-response curves (see text): for rat E14 VM this was 0.1 mg/million cells (LIF-, BDNF- and DHF-nano); for hfVM, this was 0.01 mg/million cells (LIF- and XAV-nano) and 0.1 mg/million cells (BDNF- and GDNF-nano).
Patients were divided into 2 subgroups according to dosing regimen.
Second cancer sites were grouped according to doses received from typical tangential breast fields.
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