Derangements in lipid homeostasis accompanying weight gain are due in part to genetic variation in CNR1.
Malnutrition, with accompanying weight loss, is an unnecessary risk in hospitalised persons and often remains poorly recognised and managed.
Physical inactivity and accompanying weight gain increase the risk of many chronic diseases, notably obesity, metabolic syndrome, coronary heart disease, type 2 diabetes, and certain cancers [ 9- 22].
Another reason for the inconsistency of our observations might be the possibility that weight gain during treatment with olanzapine may be associated with several biochemical mechanisms, which might manifest in a variety of clinical conditions accompanying weight gain [ 25].
Furthermore, the maintenance of glycaemic control and accompanying weight reduction observed following the switch from pioglitazone to exenatide once-weekly may be of particular clinical significance for some patients.
The effects of zoledronate in attenuating bone and cartilage loss and the accompanying weight-bearing asymmetry were more pronounced in prophylactic and early treatment protocols than in a delayed therapeutic setting [ 92].
The lasting benefit, in spite of weight regain, may derive from increased insulin sensitivity remaining from weight loss (22); mechanisms related to "metabolic memory" (23); lifestyle changes accompanying weight loss, such as improved diet or increased activity; or other unmeasured factors that differed among the weight-trajectory groups.
How can gaining weight be easier, with all the unhappiness, physical pain, and self-abuse that usually accompany weight gain?
The current study demonstrates that genetic variability in CNR1 contributes to several derangements in lipid homeostasis known to accompany weight gain.
The decrease in HDL-C level that typically accompanies weight gain is therefore of considerable importance, particularly in the context of the growing obesity epidemic.
