Acquired resistance to tumor therapy can develop as a result of de novo genetic changes that accompany the progression of cancer.
To characterize the metabolic features that accompany the progression of adiposity, male C57BL/6 mice were fed low (LFD, 10% fat), high (HFD, 45% fat) and very high (VHFD, 60% fat) fat diets, respectively.
Cardiac autonomic imbalance accompanies the progression of chronic heart failure (CHF).
Thus, widespread, subtle changes in cell surface glycosylation accompany the progression of the metastatic capacity of these cells.
The data presented in this study provide a new hypothesis for the alterations in tissue physiology that accompany the progression of the human TB granuloma to caseation.
Recent examples of such a mutator phenotype are the high mutation rates of the C of TpCpN (or its complement, G of NpGpA) that can accompany the progression of some cancers (Nik-Zainal et al., 2012; Roberts et al., 2012).
Similarly, in the lung, both myelinating and non-myelinating Schwann cells arise from neural crest precursors that migrate from the esophagus into the mouse lung at embryonic day 10.5, accompanying the progression of peripheral nerves (Deal et al., 2006).
In BALB-neuT mice Amot expression in the mammary glands becomes prominent only following the vigorous angiogenic switch that accompanies the progression of preneoplastic lesions towards invasive cancer, characterized by burgeoning capillary sprouts [ 15, 21].
The current study provides a new framework for appreciating the physiological responses to Mtb infection that accompany the progression of TB granulomas to caseation and cavitation, and ultimately disease transmission.
