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Although His is accommodated in the interface, the structural defects are propagated to the active site through a helix on the protein surface.
Overall, the structure of the V266H variant demonstrated that the inhibition could not be explained by disruption of the short-range allosteric network because the His His266′ side chains were accommodated in the interface, albeit with repositioning of neighbouring tyrosine side chains.
The X-ray crystal structure of caspase 3 (V266H) showed that the histidine side chain was accommodated in the interface, but its presence affected the structure of the active site, resulting in a narrower S1 binding pocket and a disordered loop 1.
For example, in the structure of N-CtRH complexed with its physiologic product, (3 R -hydroxy-octanoyl-CoA, the ligand is accommodated in the inteR -hydroxy-octanoyl-CoAandaR -hydroxy-octanoyl-CoAold and the complete C-teR -hydroxy-octanoyl-CoA
Similar(56)
Given that EcoRI was able to recognize and digest γ-HOPdG-modified DNA substrates, γ-HOPdG is presumed to be accommodated in the recognition interface in a manner similar to physiological substrates.
Others that are not well accommodated in the lattice tend to segregate at the interfaces between crystals and cause havoc there.
In total, 18 dating methods are accommodated in the database.
This problem is accommodated in the 'SPOCs & survey'-method.
Total mass of product accommodated in the chamber (kg).
Aberration correction and defocus for individual traps are easily accommodated in the above code at the binarization stage, and indeed are included in the full version of the shader code used by our LabView user interface.
Repeated measurements were not accommodated in the statistical analysis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com