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Perhaps this is why only a few changes to M204 are tolerated [14] while it appears that several changes can be accommodated at positions of ETVr [6].
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This model assumes that the side groups are accommodated at interstitial positions within the crystalline phase owing to 2g1 kinks of the main chain.
Such highly packed system combined with the relatively limited space of the major groove causes stereochemical restrictions over the side chains that can be accommodated at the positions 153 and 157 in order to maintain the system interactions on their total integrity.
Despite being adjacent to AVR-PikDHis46, in the Pikp-HMA/AVR-PikD complex the side chains of AVR-PikDPro47 and AVR-PikDGly48 do not contact the same Pikp-HMA monomer and Ala/Asp residues could be accommodated at these positions without disrupting the Pikp-HMA/AVR-Pik interface.
Close inspection of the Pikp-HMA/AVR-PikD interface reveals how a Glu could be accommodated at this position.
This interaction is not present in the wild-type structure and suggests that the bulky hydrophobic valine residue cannot be accommodated at this position.
The isopropyl group of PP242 is too wide to be accommodated at a critical position in the channel in PI3KCγ (7), yet overall PP242 is the smallest compound and occupies the smallest portion of the pharmacophore space.
The conformational restriction of the proline at position 1835 leads to a small shift in the main-chain conformation but is otherwise well accommodated at the N-terminus of α3′.
would be accommodated at Maja's.
Other staff were accommodated at 80 Pall Mall.
Surprisingly, however, helix 3 was able to accommodate phenylalanine at position 140 and gained a new mechanism to stabilize the helix.
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CEO of Professional Science Editing for Scientists @ prosciediting.com