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ATP was manually placed within the yeast homology model, and the protein side chains were minimized in order to best accommodate this compound.
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As compound 3 is a slightly larger molecule than compound 2, to accommodate this ligand, compound 3 had a 'tilt' through the subpocket of the active site (arrow in Figure 5A).
Interestingly, ERα accommodates this larger compound with only minimal LBP rearrangements.
To accommodate this requirement, we created HIVprotI, a web based algorithm for prediction and design of protein specific anti-HIV compounds.
Tall buildings efficiently accommodate this demand.
How to accommodate this paradox?
Independent pairwise comparisons cannot accommodate this structure.
BioC is designed to easily accommodate this added sophistication.
No, it's for the muscle, to accommodate this lump.
Several possibilities may be envisioned to accommodate this observation.
Both compounds were available in racemic form from screening vendors and initial docking studies, undertaken with the (S -configured S -configureduggestructuresthe PDE4 catalytic pocket suggested able thatccommodathethese comPDE4ds, with the N-acatalyticchains extending across its rim (Fig. 2B and C).
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