In the presence of peptide the cleft between the TPR and catalytic domains is wider to accommodate the peptide, and suggests a 'hinge' at the interface between the two domains exposes the active site.
In terms of rationalizing the differences in fidelity between the first- and second-generation nitroTyr-RSs, we note that the nitroTyr-5B RS preserves all hydrogen-bonding interactions required for Tyr binding and has a larger binding pocket in order to accommodate the NO2 moiety, suggesting that nitroTyr-5B should still be able to bind Tyr (though less favorably than nitroTyr).
The camera crew thought the entire set would have to be rebuilt to accommodate the shot, but Sallin suggested putting a dolly into the trough and controlling it from above with an offset arm.
Part of the Results section has been modified to make it clearer that MMPs are upregulated by stroke and to accommodate the additional stroke experiments (suggested in the 5th comment of the reviewers).
Conformational changes of the HCV-polymerase such as a rotation of the thumb domain or a reorientation of the C-terminus were suggested to accommodate the formation of the double-stranded RNA product.
Finally, getting a smaller-scale work accepted for performance -- on the condition that you will make any suggested alterations and accommodate the whims of the stage director, who may be a musical ignoramus.
The discussion of experiment designs includes both repeated measures and parallel groups designs together with their advantages and disadvantages and some suggested modifications to accommodate the particular problems posed by MCS.
[12] suggests that to accommodate the VBR traffic, the admission control should accept each flow with mean data rate plus a small extra value (less than the SD in case of known arrival rate traffic such as playback video).
If you can't accommodate the request, simply say so and suggest a similar alternative that the customer can eat.
Schwartz's article suggested that businesses could accommodate the growing number of working mothers by offering them alternative career paths.
