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The size of the ITS2 appears to have some bearing on the ability of the sequence to acquire non-deleterious mutations with longer sequences generally better able to accommodate mutation accumulation than shorter sequences.
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In the 1990s, Richards and collaborators used a combination of theory and experiment to investigate how the well-packed interior of proteins can nevertheless accommodate mutations.
The structural differences in homologous proteins could be due to structural re-ordering to accommodate mutations.
Although vaccines are also available for the prevention and control of influenza virus infection, they need to be frequently revised typically every 1 3 years in the case of seasonal influenza vaccines to accommodate mutations in the HA and NA proteins of the circulating viruses (antigen drift).
Consequently, backbone conformational changes may be necessary to accommodate mutations from-glycine or to-proline.
Hence, by deduction, they can accommodate mutations to amino acid types for which no rotamers fit in the original backbone.
Furthermore, highly diverse environments may also have created a wide spectrum of habitats to accommodate mutations [ 38].
Another possibility could be that the presence of one or more redundant factors can accommodate mutations in the XRCC4 gene.
We emphasize that the Flexibility Model is empirical: rather than derived from first principles, it is postulated, based on the intuitive notion that flexible sites should accommodate mutations more easily.
This is easily accounted for by the enormous selection pressure operating on the translation machinery (made of proteins interacting with each other and with highly conserved RNAs), which cannot easily accommodate mutations resulting in alteration of the corresponding proteins.
For example, these arrangements might be expected to accommodate mutations more easily because secondary structures would be more able to slide relative to each other, meaning that changes in residue size would be less likely to disrupt the core packing arrangements.
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